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Robin Whittle's avatar

Like most aspects of human ill-health, RSV would be much less of a problem if everyone had at least the 50 ng/mL circulating 25-hydroxyvitamin D their immune system needs to function properly.

25-hydroxyvitamin D, as measured in "vitamin D" blood tests, is made primarily in the liver, over several days, from ingested or production in ultraviolet-B exposed, ideally white, skin.

There's very little vitamin D3 in food, fortified or not. It can be made by UV-B skin exposure, but this always damages DNA and so raises the risk of skin cancer. Far from the equator, sufficient UV-B light is only available, from high elevation sunlight on cloud-free summer days, without being absorbed by glass, clothing, sunscreen or large amounts of melanin in the skin.

Without proper vitamin D3 supplementation, or lots of UV-B skin exposure, most people attain half or less of the 50 ng/mL 125 nmol/L (1 part in 20,000,000 by mass) level of circulating 25-hydroxyvitamin D the immune system needs to function properly.

Neither vitamin D3 cholecalciferol no 25-hydroxyvitamin D are hormones. The immune system does not use hormonal signaling. Many types of immune cell require a good supply of 25-hydroxyvitamin D, via diffusion from the bloodstream, to supply their 25-hydroxyvitamin D -> calcitriol intracrine signaling system, which operates entirely within the cell, and is crucial to the cell's ability to respond to its changing circumstances.

Please see the research cited and discussed at: https:// vitamindstopscovid.info/00-evi/.

It is easy to find research of specific interest for RSV, with a Google Scholar search for:

RSV "vitamin D"

https://scholar.google.com.au/scholar?hl=en&as_sdt=0%2C5&q=RSV+%22vitamin+D%22&btnG=

For recommendations (from New Jersey based Professor of Medicine Sunil Wimalawansa) on how much vitamin D3 to supplement, as a ratio of body weight - with higher ratios for those suffering from obesity - please see: https:// vitamindstopscovid.info/00-evi/#00-how-much. These recommendations are now in a peer-reviewed journal article he wrote with another professor of medicine and a professor of pediatrics, all of them long-time vitamin D researchers: https:// www.sciencedirect.com/science/article/pii/ S2405844024107220.

These recommendations are intended to safely raise the circulating 25-hydroxyvitamin D level to at least 50 ng/mL, with no need for blood tests or medical monitoring. 70 kg (154 lb) adults need about 1/8th of a milligram of supplemental vitamin D3 a day, on average, in order to attain (over several months) at least the 50 ng/mL circulating 25-hydroxyvitamin D they need for full immune system function.

This is 125 micrograms = 0.125 milligrams and is also known by the frighteningly high number of 5000 IUs ("International Units"). An IU is a cranky old unit from a century ago: 1/40,000,000 th of a gram of vitamin D3.

"5000 IU"s sounds like a lot, but it is a tiny amount. Meanwhile, many doctors recommend only 1000 IU a day (a gram every 110 years) vitamin D3 supplementation, which may raise the 25-hydroxyvitamin D of average weight adults to about half of the 50 ng/mL needed for proper immune system function.

Newborns' 25-hydroxyvitamin D levels depend directly on their moms'. Measurements of vitamin D3 and 25-hydroxyvitamin D levels vary widely, in part due to the difficulties in measuring such low levels: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2023.1229445. One recent study https://www.mdpi.com/2072-6643/13/2/573 found approximately equal amounts of vitamin D3 and 25-hydroxyvitamin D in human breast milk. Since (at least in adults) the liver only coverts about 1/4 of ingested vitamin D3 into circulating 25-hydroxyvitamin D, this means that the bulk of the benefit to the breast-fed child's 25-hydroxyvitamin D comes from the 25-hydroxyvitamin D component of breast milk. This depends on the mother's 25-hydroxyvitamin D level.

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GeoffPainPhD's avatar

All part of the Pfizer master plan, when competitors RSV Jabs "drop out of the market".

https://geoffpain.substack.com/p/pfizer-appoints-chris-boshoff-who

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